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Find out about the origin, effects and applications of Muscimol
Muscimol is a psychoactive alkaloid that occurs in various mushroom species, particularly the fly agaric (Amanita muscaria). It is formed by decarboxylation of ibotenic acid, which is contained in these mushrooms. Muscimol was discovered and isolated independently by several research groups in the first half of the 1960s during analytical work on the ingredients of Amanita mushrooms.
Muscimol acts as an agonist at the GABA-A receptors in the central nervous system. By binding to these receptors, neuronal activity is inhibited, which can lead to sedative, calming and hallucinogenic effects. This effect is similar to that of gamma-aminobutyric acid (GABA), a natural neurotransmitter responsible for inhibiting neuronal activity.
Traditionally, muscimol has been used for ritual and spiritual purposes in various cultures. In modern times, it is used in scientific research to study its effects on the central nervous system. There are also reports of muscimol being used in the treatment of depression, although more research is needed to confirm its effectiveness and safety.
Purchasing muscimol is unregulated in many countries, including Europe. However, it is important to be aware of the current legal regulations in your country, as these may change. When purchasing, attention should be paid to the quality and purity of the product in order to minimize health risks.
Muscimol should be stored in a cool, dry place, protected from light to ensure its stability. It is advisable to store the product in an airtight container to minimize contact with moisture and air. Since muscimol is available in different forms, such as dried mushrooms or as an extract, the manufacturer’s specific storage recommendation should be followed.
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Muscimol has a calming, relaxing and partially hallucinogenic effect. It can alter consciousness, intensify perception and, in higher doses, induce sleep. The effect depends largely on the dosage and individual sensitivity.
The legal situation of muscimol varies from country to country. In many countries, the consumption or possession of mushrooms containing muscimol is not directly prohibited, as these mushrooms are often not subject to narcotics law. However, the sale and processing can represent legal gray areas.
Traditionally, muscimol is consumed by eating dried or prepared fly agarics. Some users make tea from the mushrooms to extract the active compounds. However, it is important to know the correct dosage, as the mushroom also contains ibotenic acid, which can be toxic and must be converted to muscimol.
No, muscimol is not considered addictive. It does not develop physical or psychological dependence. However, repeated abuse can lead to negative psychological effects, which is why responsible use is important.
The effects of muscimol usually begin within 30 to 120 minutes after ingestion and can last between 4 and 8 hours. However, after-effects such as a feeling of relaxation or mild tiredness may be felt for even longer.
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