CBD Side Effects

The most frequently reported side effect with CBD is fatigue or drowsiness. CBD interacts with the endocannabinoid system and can have a relaxing effect, which can lead to a feeling of numbness at higher doses. In clinical studies, up to 25% of participants reported fatigue. This effect is dose-dependent and occurs mainly when taken early in the day or in combination with other sedative substances. Tip: start with a low dose in the evening to assess your individual reaction.

Dry mouth (also called 'cottonmouth') occurs because cannabinoids influence the salivary glands. CB1 and CB2 receptors are found in the submandibular salivary glands, and their activation can temporarily reduce saliva production. This effect is generally mild and can be easily managed by sufficient fluid intake. Sugar-free gum can also help stimulate saliva production.

CBD can both increase and decrease appetite – the effect varies from person to person. Unlike THC, which typically increases appetite (the famous 'munchies' effect), CBD tends to reduce it. In the clinical study on Epidiolex, about 16% of patients reported a decrease in appetite. Weight changes have also been documented, with both weight gain and loss observed.

Diarrhea and nausea are among the most frequently reported side effects, especially at higher doses. In the approval studies of Epidiolex, diarrhea occurred in about 9 to 20% of patients. These issues are often not due to CBD itself, but also to carrier oils (such as MCT oil) or other ingredients. Taking with a meal can help reduce digestive issues.